![]() Although many buccal films have been reported in literature employing various combinations of synthetic/semisynthetic as well as natural polymers, the amalgamation we have selected is novel and has not been reported for glimepiride to the best of our knowledge. Methocel was employed as the central rate controlling polymer in the proposed matrix system, and the effect of combinations of polymers was scrutinized for different film parameters. A combination of new (Ultrez-21, Pluronic F68) and conventional polymers (Methocel, Eudragit RL100) was chosen for development of buccoadhesive films. ![]() To date, glimepiride has not been explored for buccal delivery although it is one of the suitable candidate for buccal route owing to its low dose (1–4 mg), low molecular weight (490.61), and high partition coefficient (3.5) ( 6). In order to overcome this problem, it has been delivered via transdermal route and a significant reduction in blood glucose level was observed in comparison to oral delivery ( 5). Glimepiride was chosen as a model drug as it exhibits very poor aqueous solubility (0.001908 mg/mL) leading to slow dissolution in the gastrointestinal environment and poor bioavailability. In the present research, substantial efforts have been put to develop films and to explore physicomechanical parameters of films, implementing new instrumental techniques, which assure reproducible results than age old methods used in the evaluation of film strength, buccoadhesive and tensile strength of films/patches. Moreover, mucoadhesive preparations included in the European Pharmacopoeia 7.4 (2012) have encouraged researchers to utilize the advantages of the technique in drug delivery research ( 4). carvedilol, lidocaine, salbutamol, and miconazole as buccoadhesive films/patches have been referenced in scientific texts ( 2, 3). Experimental evidences on better therapeutic efficacy of drug molecules viz. dose accuracy, small and compact size, local or systemic action, swift absorption of the drug, ease of withdrawal in urgent situation, controlled and/or sustained release, prevention of gastric degradation or first-pass effect, and comparatively better stability than other buccoadhesive systems (cream, gel, ointment) ( 1). These formulations (films and patches) are the representative systems of transdermal patches and have many advantages viz. Stability studies revealed no significant ( P < 0.05) variation in physicomechanical characteristics.īuccoadhesive systems are one of the novel formulation techniques, where polymers play a central role. Films were compatible with oral probiotic microorganisms. Film GM4 exhibited 98 ± 2% in vitro drug release and 85 ± 8% ex vivo drug permeation in 12 h with controlled diffusion mechanism. Erosion behavior of films was observed in swelling and SEM studies. ![]() ![]() ![]() Buccoadhesion was also influenced by particle size (adsorption theory) and swelling (wetting theory). Increase in polymer concentration augmented zeta potential of polymeric matrix-mucin mixture and exhibited strong buccoadhesion (electrical theory). Drug-polymer interaction was examined by FTIR and DSC analysis. The present study aimed to develop buccoadhesive film of glimepiride with unique combination of polymers and to investigate its effect(s) on physicomechanical parameters, drug-release, and permeation of films. ![]()
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